“What made Pfizer change this criterion? My speculative answer is that Pfizer knew that Paxlovid did not work in the vaccinated. Having failed to hit the target when it came to vaccinated people, Pfizer decided to remove them from the trial and “move the target,” so to speak. This way, the EPIC-SR study would end up being a “success,” technically.”

https://igorchudov.substack.com/p/did-pfizer-know-that-paxlovid-will?s=r